- Leukotriens (LTS), in general, appear to act as mediators in inflammation and anaphylaxis.
- Capillary dilatation and vascular permeability.
- As little as one n-mole of LTC4, D4, and E4 elicits erythema, and wheal formation like histamine also increase vascular permeability.
- Action on bronchial muscles: Inhalation of LTS causes bronchospasm.
- SRS-AC slow reacting substance of anaphylactic
- SRS-A, which is produced by most cells during anaphylactic reaction, has now been shown to have a mixture of LTS like LTS C4,D4, and E4. These leukotrienes are responsible for intense vasoconstriction of bronchial muscles, vasodilation, and increased vascular permeability seen in anaphylactic/allergic reactions.
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