| 1836 | – | Berzelius coined the term catalysis. |
| 1878 | – | Kuehne worded the word enzyme. |
| 1883 | – | Buchner isolated enzyme from yeast zymase. |
| 1926 | – | James Sumner isolated from Jack Beans. He got noble prize in 1940. |
| 1930 | – | Northrop crystallised proteolytic enzyme from gastrointestinal tract. |
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