A suppository is a solid or semisolid mass meant to be inserted into any of the body orifices such as rectum, vagina, ear, nasal, and urethra to provide either local or systemic effect. They are designed to soften and melt or to dissolve or disintegrate at the body temperature. Suppositories provide systemic effect when used rectally. They are frequently used for local effects for relief of hemorrhoids or infections in the rectum, vagina, or urethra. Suppositories contain medicaments such as emollients, astringents, antiseptics, and local anesthetics, which are designed to exercise local action at the site of placement. Suppository bases are classified into oleaginous base and water-soluble and water-miscible base. Suppositories are classified into two types. The first one depends upon the route of administration—rectal suppositories, vaginal suppositories or pessaries, urethral bougies, and nasal bougies. The second one depends upon the pharmaceutical design—tablet suppositories, capsule suppositories, and coated suppositories.