Place each of the capsules in the apparatus-1 of dissolution tester, excluding air bubbles from the surface of the capsule. Operate immediately at specified rate within specified dissolution medium at 37 ± 0.5 °C. Aliquots should be withdrawn at specified time points or as mentioned in individual monograph and the volume of withdrawn sample should be replaced with the fresh media to maintain the sink conditions. The withdrawn aliquots are suitably diluted and analyzed for the percentage drug release by following reported analytical procedure and instrument.
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