A mixture is a liquid preparation intended for oral administration, in which the drug is dissolved, suspended or dispersed in a suitable vehicle. In general, several doses are contained in a bottle. A simple mixture contains only soluble ingredients. Advantages of a simple mixture are as follows:
- It can be given to children and geriatric patients having difficulty in swallowing tablets and capsules.
- It has a faster onset of action.
- The uniformity of dose is maintained.
- It provides pleasant appeal to the patients.
However, a simple mixture suffers from the following drawbacks:
- It has lesser stability than solid dosage forms.
- It is difficult to mask the unpleasant taste of some drugs.
- It is difficult to carry due to the bulk and weight.
- Accidental breakage leads to complete loss.
Example
Weak iodine solution or tincture of iodine I.P.
| Iodine | 2.0 g | |
| Potassium iodide | 2.5 g | |
| Alcohol (50% v/v in water) (q.s.) | 100 ml |
Potassium iodide and iodine react together to form polyiodides, which enhance the solubility and provide a more stable solution. Potassium iodide and iodine are triturated in a pestle and mortar with sufficient quantity of 50% alcohol. After complete solubilization of iodine, more vehicle is added to make up the volume to the required level.
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