- The dispersed particles should settle slowly and should redisperse immediately on shaking.
- The product should remain sufficiently homogenous for at least the period between shaking the container and removing the required dose.
- The viscosity of the suspension should be such that it can be easily removed from the container and transferred to the site of application without any difficulty.
- The sediment produced on standing should not form a hard cake.
- Any suspended particles should be small and uniformly sized in order to give a smooth, elegant product free from grittiness.
- The suspension should be physically and chemically stable during handling and storage conditions.
- It should have good syringibility in case of parenteral suspensions.
- It should produce thixotropic property (gel to sol upon shaking and sol to gel during storage).
Advantages of Suspensions
- Insoluble drugs may be made more palatable.
- Insoluble drugs may be prepared in a more stable manner.
- Suspended insoluble powders are easy to swallow.
- Suspensions enable easy administration of bulk insoluble powders.
- When compared to solid dosage forms, absorption is faster.
- Lotions will leave a cooling layer of medicament on the skin.
- It can be formulated for both immediate and sustained drug release preparations.
Disadvantages of Suspensions
- Suspensions require shaking before use, to ensure uniformity of dose.
- If the preparation is not shaken well, the accuracy of dose is likely to be less when compared to solutions.
- Improper storage conditions can affect the disperse system.
- Since suspensions are stored in glass or plastic containers, they are bulky, difficult to transport and prone to container breakages.
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