VLDL are rich in Triglycerides (TG) and are derived mainly from liver and secreted by the intestines in a manner similar to that of chylomicrons. The particle size is smaller than chylomicrons (CM), and the apoproteins of VLDL include apo-B48 and apo-C.
Chylomicrons are rich in triglycerides and are derived from intestinal absorption of lipids. They are secreted from the intestinal mucosal cells into the intracellular fluid. Chylomicrons are responsible for transport of all dietary lipids into circulation. The principal apoprotein component of chylomicron in apo-B-48, which is incorporated into the chylomicron in the intestine itself. This…
Structure of Lipoproteins Lipoproteins are produced when proteins combine with lipids such as phospholipids, lecithin, cephalin, fatty acid, cholesterol, glycerides, and fat-soluble vitamins Figure 4.5. Figure 4.5 Structure of Lipoprotein The density of lipoproteins is lower than that of proteins because of their combination with lipids. Because of this property, the different fractions of lipoprotein can be…
Polyunsaturated fatty acids are the structural elements of mitochondrial membrane. Mitochondrial membrane loses its activity when there is deficiency of EFA, which may cause swelling and reduction of oxidative phosphorylation. Fats with a high content of polyunsaturated fatty acids lower the serum cholesterol level. Inadequate EFA may lead to a fatty liver. Docosahexaenoic acid (22:6n-3)…
The emulsification of dietary fats in the intenstinal canal, brought about by bile salts, is a prerequisite for digestion and absorption of fats.