Labeling of Powders and Granules The following information should be there in the labels of powders and granules: Storage Conditions
Pharmaceutical powder particles range from about 10 mm in diameter to 1 micron or less. Particle size analysis is helpful in the determination of size, shape, distribution of drug and other components used in pharmaceutical formulations. Powder particle size influences a various physical and physiological factors. They are as follows: Methods of particle size analysis
Granules are agglomerates of powders. Depending upon the application, various granules of different size can be prepared. The usual size ranges of granules are in the range of 4–12 sieve. Advantages of Granules
In the preparation of powders, some special modifications are followed for incorporation of some of the substances. The modified procedures are as follows:
The classification of powders is as follows:
Learning Objective A powder is a homogenous mixture of more or less finely divided particulate material in dry form. Although the use of powders as a SDF has declined yet they are the starting material in the manufacture of many dosage forms. Powders are one of the oldest dosage forms and are used both internally…
Wet Seal Cachets They are made up of two similar convex halves having flat edges. The weighed amount of powder is placed in one half. The edges of the other are moistened with water and placed exactly over the first half containing the powder. Edges of both the halves are pressed together so as to…
Disadvantages
Learning Objective Cachets or wafer capsules are unit solid oral dosage forms in which drug is enclosed in a tasteless sheet formed by pouring a mixture of rice flour and water between two hot polished revolving cylinders. The water evaporates and a sheet of wafer is formed, which is termed as cachets.