During production of tablets, defects arise with finished tablets, which may be due to fault in the formulation or in the tableting equipment and sometimes due to both of these reasons. Table 5.2 details few common production problems that arise during manufacturing.   Table 5.2 Production Problems with Tablet Quality Tablet Problems Possible Causes Corrective Action 1. Non-uniform…

The various process steps involved in wet method are as follows:

Direct compression: Most manufacturers agree that direct compression is superior with few steps since it does not require much equipments and handling expenses as required for wet method of tablet manufacture. The medicaments with large doses having good bulk density, flowability and compressibility can be directly compressed. There are few crystalline substances such as inorganic salts…

Learning Objective Compressed tablets are manufactured by the following two methods:

Learning Objective Compressed tablets usually contain active medicament/s mixed with a number of inert substances known as excipients or additives. These additives are added to give good quality tablets. Although these additives are termed inert, they have great influence on stability, bioavailability and process by which dosage forms are prepared. According to the activity of…

Learning Objective Definition Tablets are unit SDF each containing a single dose of one or more active medicaments with or without excipients prepared by molding or compression method. Advantages Disadvantages

Solid dosage forms (SDFs) are the drug delivery devices formulated as both single and bulk dose forms suitable for oral administration. It mainly comprises of tablets, capsules, cachets, pills, powders and granules (Fig. 5.1). The oral route offers several advantages such as accurate dosing, physicochemical integrity of the active medicament, elegant appearance, flexibility in formulating…