Although an aqueous vehicle is generally preferred for an injection, it may be unacceptable if the drug has limited water solubility or is susceptible to hydrolysis. When such physical or chemical factors limit the use of an aqueous vehicle, then the only alternative is to use nonaqueous vehicles. Examples of nonaqueous solvents employed in parenteral…

Vehicles used for parenteral preparations should possess the following characteristics: Vehicles used for parenteral preparations are classified as follows: Aqueous Vehicles

Learning Objective

Learning Objective General Criteria for Design of Suitable Injectable Formulations The following precautions are to be considered when preparing drug solutions and suspensions intended for injection:

According to the United States Pharmacopoeia (USP), injectable preparations are classified into five general types: The nature of the drug, with respect to certain therapeutic considerations and its physical and chemical properties, decides the form in which the drug is prepared for parenteral use by the manufacturer. If a drug is unstable in solution, it…

Intradermal Route lntra-arterial Route Intrathecal Route