Category: Lipid Metabolism


  • Adrenal cortex, ovaries, testis, cytoplasm, and mitochondria are the sites of synthesis of bile salts.

  • Cholesterol is the precursor for the synthesis of five classes of steroid hormones:   Glucocorticoids Example: Cortisol Mineralocorticoids Example: Aldosterone Progestins Example: Progesterone Androgens Example: Testosterone Estrogens Example: Estradiol

  • Bile Salts

    Bile salts leave the liver as a molecule conjugated to either glycine or taurine by an amide linkage between the carboxyl group of the bile acid and the amino group on the added compounds. These modified structures are called bile acids, which include glycocholic acid, chenodeoxycholic acid, taurocholic acid, and taurochenodeoxycholic acid.

  • Bile Salts

    Bile salts leave the liver as a molecule conjugated to either glycine or taurine by an amide linkage between the carboxyl group of the bile acid and the amino group on the added compounds. These modified structures are called bile acids, which include glycocholic acid, chenodeoxycholic acid, taurocholic acid, and taurochenodeoxycholic acid.

  • Cholesterol is degraded to bile acids by a multi-step pathway, in which the hydroxyl groups are inserted at specific positions on the steroid structure of cholesterol; the double bond of B-ring is reduced. The hydrocarbon chain is shortened by three carbons, introducing a carboxyl group at the end of the chain. The resulting compounds, cholic…

  • Primary bile acids are synthesised in liver from cholesterol.

  • The bile acids contain twenty-four carbons, with two or three hydroxyl groups and a side chain that terminates in a carboxyl group.