Learning Objective Cachets or wafer capsules are unit solid oral dosage forms in which drug is enclosed in a tasteless sheet formed by pouring a mixture of rice flour and water between two hot polished revolving cylinders. The water evaporates and a sheet of wafer is formed, which is termed as cachets.
Place each of the capsules in the apparatus-1 of dissolution tester, excluding air bubbles from the surface of the capsule. Operate immediately at specified rate within specified dissolution medium at 37 ± 0.5 °C. Aliquots should be withdrawn at specified time points or as mentioned in individual monograph and the volume of withdrawn sample should…
Inhibition can occur during two reactions in glycolysis. Glyceraldehydes 3-phosphate + H3Po4 → 1,3-diphosphoglyceric acid + NADH + H+ Figure 8.7 Graphical Representation of Allosteric Inhibition of Phosphofructokinase with Respect to ATP Concentration This reaction may be inhibited by iodoacetate; arsenate can also interfere with this reaction, not by inhibition, but by competing with phosphate in the…
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