The plant kingdom has been the source of several drugs of indispensable value to modern medicine. Plant drug isolations have come a long way from the limited methods of isolations of high-yield active constituents to high-speed extraction techniques now available for the rapid detection and isolation of trace quantities of active constituents even from plant parts. Today commercially feasible techniques are available for extraction of several phytomolecules. Isolation, identification and estimation methods of a few selected plant-derived pure drugs have been discussed.