Fusion Method

This method is applicable to melt multiple ingredients, especially when an ointment base contains a number of solid ingredients such as white beeswax, cetyl alcohol, stearyl alcohol, stearic acid, and hard paraffin. The components of the formula are melted in the decreasing order of their melting point in the grated form. That is, the substance with the highest melting point should be melted first followed by the substance with the next-highest melting point and so on. The medicament is added slowly into the melted base with intense stirring until the mass cools down and a homogeneous product is formed at the room temperature.

Example:

Simple ointment I.P.

 

Wool fat50g
Hard paraffin50g
Cetostearyl alcohol50g
White soft paraffin850g

 

Type of preparation: Absorption ointment base

 

Hard paraffin and cetostearyl alcohol in grated form are introduced into the preheated china dish placed over a water bath. Wool fat and white soft paraffin are mixed and stirred until all the ingredients are melted completely. If necessary, they are decanted or strained and stirred until cold and packed in a suitable container.


Leave a Reply

Your email address will not be published. Required fields are marked *