Lactate, which is produced in the skeletal muscle, is the precursor for gluconeogenesis. In anaerobic conditions, pyruvate is reduced to lactate by using lactate dehydrogenase. Lactate is the end product of glycolysis, since it must be reconverted to pyruvate for its further metabolism. Lactate is carried from the skeletal muscle through blood and handed over to the liver, where it is oxidised to pyruvate. Pyruvate so formed is converted back to glucose through gluconeogenesis pathway and further transported to the skeletal muscle. The cycle involving the synthesis of glucose in the liver from skeletal muscle lactate and the reuse of glucose by the muscle for the energy purpose is known as ‘Cori cycle’.