Immunoglobulin or gamma globulin is obtained from the globulins fraction separated during the final stage of fractionating the plasma. Figure 10.2 shows the fractionation process.

Figure 10.2 Fractionation of Immunoglobulins or Gamma Globulins

The immunoglobulins are dissolved in a suitable solvent, usually 0.8% sodium chloride solution, and a preservative, such as 0.01% of thiomersal, is added. The solution is sterilized by filtration and packed in single-dose containers.

Storage: The solution should be stored at 4°C–6°C, with protection from light.