Learning Objective
Learning Objective Absorbable sutures are those that are broken down in the body after a period of time. The time of degradation of the material in the body varies from days to weeks. They are used for internal body tissues where the suture eventually dissolves after performing the function. The advantage in such type of…
INTRODUCTION Surgical ligatures and sutures are the threads or strings specially prepared and sterilized for use in surgery. The term ligatures is mainly applied for those used in tying of blood vessels, whereas the term sutures is applied for those used in sewing tissues together. HISTORICAL BACKGROUND Sutures and ligatures have been used by surgeons…
Therapeutic incompatibility arises as a result of prescribing certain categories of drugs to patients with a sole intention of achieving a specific degree of pharmacological action. However, the nature or intensity of the resultant activity is quite different from that intended by the prescriber. Therapeutic incompatibility results due to the following reasons:
Learning Objective Mixtures with chemical incompatibilities are as follows:
Learning Objective The following are the various types of mixtures with physical incompatibilities:
Learning Objective Incompatibility may be defined as mixing two or more antagonistic substances resulting in an undesirable product, which may affect the safety, efficacy and appearance of the preparation. There are three types of incompatibilities:
Solid lipid nanoparticles (SLN) are solid colloidal particles that consist of biocompatible, biodegradable lipid matrix and exhibit size range between 100 nm and 400 nm. When administered parenterally, they showed protection of incorporated thermolabile drugs from degradation, good physical stability, controlled drug release depending on the incorporation of model, good tolerability and site-specific targeting. An…
Drug into unilamellar and multilamellar vesicles and complexation of drug with lipids have been devised for intravascular administration. Semisolid phospholipid dispersion of vesicular morphology, termed as vesicular phospholipid gels, is another approach in liposomal technology. Examples for vesicular phospholipid gels formulations are erythropoietin protein and cetrorelix peptide.