Weigh 20 suppositories individually and calculate the average mass. When the suppositories are weighed singly, the deviation of individual mass from the average mass should not exceed the limits as indicated in Table 7.4. Table 7.4 Deviation of Individual Mass of Suppositories from Average Mass Deviation % Number of Suppositories ±5 Minimum 18 ±10 Maximum 12…
Visual Inspection The suppositories are visually inspected for its physical appearance, size, shape and texture. Individual suppositories should be examined for cracks and pits due to entrapment of air in the molten mass. Disintegration Test The disintegration test can be determined by using the tablet disintegration test apparatus with necessary modification in the test media.…
Learning Objectives Displacement Value The volume of a suppository from a particular mold is uniform but its weight will vary because the densities of medicaments usually differ from the density of the base. Hence, it becomes necessary to calculate the displacement value of the base to be used for the particular medicament. Definition: The number…
Theobroma oil (Cocoa butter): It is obtained from whole and roasted seeds of cocoa bean. It occurs as a yellowish-white solid with chocolate-like odor. It contains a mixture of glyceryl esters of stearic acid and palmitic, oleic, and other unsaturated fatty acids. The advantages of this base are as follows: The following are its disadvantages: Synthetic…
Learning Objectives Suppositories are unit solid preparations, which may contain one or more active medicaments intended for insertion into the body cavities other than mouth. They are normally used for local action or systemic absorption of the active ingredient. They usually melt, soften, or dissolve at body temperature. They may be inserted into rectum, vagina,…
The jellies must be formulated with suitable preservatives such as methyl paraben 0.1–0.2% if intended for long-time use, as the jelling agents used are most likely from natural sources. They must be suitably preserved since all jellies contain large amount of water. Loss of water can quickly lead to scaly form of jellies. Glycerol, propylene…
Pharmaceutical jellies are usually prepared by adding a thickening agent such as tragacanth or carboxy methylcellulose (CMC) to an aqueous solution in which the drug has been dissolved. The mass is then triturated in a mortar until a uniform product is obtained. The following gelling agents are used for the preparation of jellies.