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    August 7, 2024
    Amino Acid Metabolism

    Urea is processed in two locations; the synthesis occurs in liver and it is transported to kidney for excretion. Urea cycle was first described by Hans Krebs and Kurt Henseleit in 1932. Hence, this cycle is also known as Krebs–Henseleit cycle.

  • UREA CYCLE

    August 7, 2024
    Amino Acid Metabolism

    Urea is the end product of protein metabolism. The nitrogen of amino acids converted to ammonia is toxic to the body. It is converted to urea and detoxified. As such, urea accounts for 80%–90% of the nitrogen-containing substances excreted in urine.

  • Phase Inversion

    August 7, 2024
    Liquid Dosage Forms

    This is the process when an O/W emulsion changes to a W/O emulsion or vice versa. As already mentioned, soaps of monovalent metals produce O/W emulsions, whereas soaps of divalent metals produce W/O emulsions. The emulsion type is determined by the solubility of the emulsifying agent. If it is more soluble in water than in…

  • Creaming

    August 7, 2024
    Liquid Dosage Forms

    Creaming is the separation of an emulsion into two regions, one of which is richer in the disperse phase than the other. It is not a serious instability problem as a uniform dispersion can be reobtained by shaking the emulsion. However, there may be coalescence of droplets as they are present close to each other.…

  • DECARBOXYLATION

    August 7, 2024
    Amino Acid Metabolism

    Amino acids are converted to the respective amines by decarboxylation process. This is carried out by a group of enzymes called decarboxylase. The coenzyme involved in the reaction is PLP (pyridoxal phosphate). Biogenic amines, which have important functions, are synthesised by PLP decarboxylation. Serotonin – Neurotransmitter regulates sleep, behaviour, and blood pressure. Histamine – Vasodilator lowers BP,…

  • Cracking

    August 7, 2024
    Liquid Dosage Forms

    The globules of the disperse phase coalesce together and form a separate layer. Redispersion cannot be achieved by shaking and the preparation is no longer an emulsion. Cracking may be caused by the following:

  • Instabilities in Emulsions

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective An emulsion is a thermodynamically unstable preparation. So, care has to be taken to maintain the physical and chemical stability of the preparation throughout its shelf life. There should be no appreciable change in the mean particle size or the size distribution of the droplets of the dispersed phase. The droplets of the…

  • Calculation of Primary Emulsion Formula

    August 7, 2024
    Liquid Dosage Forms

    The amount of emulsifying agent used is dependent on the amount and type of oil to be emulsified. Oils can be divided into three categories: fixed oils, mineral oils and volatile oils. (Note: Gum is the emulsifying agent or emulgent.) These proportions are important when making the primary emulsion to prevent the breaking down of emulsion…

  • Preparation of Emulsions

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective The preparation of an emulsion involves two stages:

  • Formulation of Emulsions

    August 7, 2024
    Liquid Dosage Forms

    The formulation of emulsions involves the following:

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