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  • Glutamate Dehydrogenase

    August 7, 2024
    Amino Acid Metabolism

    In the process of transamination, the amino groups of most amino acid are transferred to α-ketoglutarate to produce glutamate. The glutamate serves as a collection centre for amino groups in the biological system. Glutamate rapidly undergoes oxidative deamination catalysed by glutamate dehydrogenase (GDH) to liberate ammonia. This enzyme is unique, in that it can utilise either NAD+ or…

  • August 7, 2024
    Liquid Dosage Forms

    Dilution Test or Miscibility Test Dilute the emulsion with water or oil When diluted with water, emulsion is stable When diluted with oil, emulsion is stable When diluted with oil, cracking occurs When diluted with water, cracking occurs 2. Dye Solubility Test or Staining Test An oil-soluble or water-soluble dye is added to the emulsion…

  • Oxidative Deamination

    August 7, 2024
    Amino Acid Metabolism

    Oxidative deamination is the liberation of free ammonia from the amino group of the amino acid coupled with oxidation. This takes place mostly in liver and kidney. The purpose of oxidative deamination is to provide NH3 for urea synthesis and α-keto acid for a variety of reactions, including energy generation.

  • Advantages and Disadvantages of Emulsions as Dosage Forms

    August 7, 2024
    Liquid Dosage Forms

    The following are the advantages of using emulsions as dosage forms: The following are the disadvantages of using emulsions as dosage forms: Learning Objective The tests that can be performed to distinguish between O/W and W/O emulsions are given below (Table 6.7): Table 6.7 Tests to distinguish between O/W and W/O Emulsions Sl. No. O/W Emulsion…

  • Microemulsions

    August 7, 2024
    Liquid Dosage Forms

    Clear dispersions of oil in water or water in oil are called microemulsions. The disperse phase globules are very small, ranging in diameter from 100A° to 600A°. These emulsions appear as transparent solutions and are more acceptable physically as compared to conventional emulsions. Self-emulsifying Systems These are anhydrous products that when added to excess of…

  • EMULSIONS

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective Emulsions are biphasic heterogeneous systems consisting of two immiscible phases, one of which (the dispersed phase) is finely subdivided and uniformly distributed as droplets throughout the other (the dispersion medium). An emulsion is rendered homogeneous by the addition of an emulsifying agent. The emulsifying agent ensures that the droplets (dispersed phase) is finely…

  • DEAMINATION

    August 7, 2024
    Amino Acid Metabolism

    The removal of amino group from the amino acid as NH3 is termed as deamination. Transamination involves only the shuffling of amino groups among the amino acids. On the other hand, deamination results in the liberation of ammonia for urea synthesis. These reactions occur primarily in liver and kidney and provide α-keto acid (which can enter the central…

  • Marketed Formulations

    August 7, 2024
    Liquid Dosage Forms

    Lacto Calamine (Nicholas Piramal) Caladryl (Pfizer) Calak Lotion (SPPL) Dey’s Milk of Magnesia (Dey’s) Digene Gel (Abbott) Gelupin-MPS (Lupin) GelusiL-MPS (Pfizer) Advent Forte (Dry powder suspension for reconstitution—amoxycillin and clavulanate potassium)

  • Evaluation of Suspensions

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective The following are the tests to determine the stability of suspensions:

  • TRANSAMINATION REACTION DEPENDENT ON PYRIDOXAL PHOSPHATE

    August 7, 2024
    Amino Acid Metabolism

    Formation of enzyme pyridoxal phosphate-Schiff base and amino add-pyridoxal phosphate Schiff base.

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