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  • Suspensions Containing Poorly Wettable Solids

    August 7, 2024
    Liquid Dosage Forms

    Some substances such as sulfur and hydrocortisone are both insoluble in water and poorly wetted by it. When preparing simple aqueous dispersions, it is difficult to disperse clumps and the foam produced on shaking is slow to subside because it is stabilized by the film of unwettable solid at the liquid–air interface. To ensure satisfactory…

  • MECHANISM OF TRANSAMINATION

    August 7, 2024
    Amino Acid Metabolism

    Involvement of pyridoxal phosphate in the transfer of amino group.

  • Methods of Dispensing Suspensions

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective Suspensions Containing Diffusible Solids The method of preparation of suspensions containing diffusible solids is as follows: Suspensions Containing Indiffusible Solids The thickening agents used in indiffusible suspensions are given below: Suspensions Containing Precipitate-forming Liquids Liquid preparations containing resinous matter when mixed with water show precipitation of resin, which sticks to the sides of…

  • MECHANISM OF ACTION OF AMINO TRANSFERASE

    August 7, 2024
    Amino Acid Metabolism

    All amino transferase requires the coenzyme pyridoxal phosphate (a derivative of vitamin B6), which is covalently linked to an e-amino group of a specific lysine residue at the active site of the enzyme (Schiff base) as shown in Figure 9.4. Amino transferase transfers the amino group from an amino acid to the pyridoxal part of the…

  • Formulation of Suspensions

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective The formulation of a suspension involves the following:

  • Based on Use or Application

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective

  • SGOT (Serum Glutamate Oxaloacetate Transferase)

    August 7, 2024
    Amino Acid Metabolism

    Serum glutamate oxaloacetate transferase, also known as aspartate transaminase (AST), is the exception to the rule that amino transferase funnels amino groups to form glutamate. AST transfers amino groups from glutamate to oxaloacetate, thus forming aspartate, which acts as a source of nitrogen in the urea cycle.

  • Based on Flocculated and Deflocculated Systems

    August 7, 2024
    Liquid Dosage Forms

    Learning Objective The suspensions are said to be flocculated when the individual particles are in contact with each other to form loose aggregates or a network-like structure. They are easily redispersible, but the rate of sedimentation is fast, the product will look inelegant and there is also a danger of an inaccurate dose being administered.…

  • SGPT (Serum Glutamate Pyruvate Transferase)

    August 7, 2024
    Amino Acid Metabolism

    Serum glutamate pyruvate transferase is present mostly in liver. This enzyme catalyses the transfer of the amino group from alanine to α-ketoglutarate, resulting in the formation of pyruvate and glutamate. This reaction is reversible, so during amino acid metabolism the enzyme proceeds towards the direction of glutamate synthesis. Thus, glutamate is considered to be the collector…

  • Classification of Suspensions

    August 7, 2024
    Liquid Dosage Forms

    Based on Type of Solids Learning Objective

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