Disadvantages
Learning Objective Cachets or wafer capsules are unit solid oral dosage forms in which drug is enclosed in a tasteless sheet formed by pouring a mixture of rice flour and water between two hot polished revolving cylinders. The water evaporates and a sheet of wafer is formed, which is termed as cachets.
Learning Objective Vitrellae are thin-walled glass capsules containing a volatile ingredient and protected by absorbent cotton wool and an outer silk bag. During its use, the capsule is crushed and the vapor is inhaled. Liquid inhalation: Amyl nitrite 0.2 ml/dose
Learning Objective Pastilles (also known as troche) are a type of candy or medicinal pill made of a thick liquid that has been solidified and is meant to be consumed by light chewing and allowing it to dissolve in the mouth. They are made by transferring a liquid, which is viscous into a mold with added…
Learning Objective A pill is a small, round and unit solid pharmaceutical oral dosage form that was in use before the advent of tablets and capsules. They are prepared by blending or mixing the active ingredients with selected excipient glucose syrup in a mortar and pestle resulting in a paste, then rolling the resultant mass…
Place each of the capsules in the apparatus-1 of dissolution tester, excluding air bubbles from the surface of the capsule. Operate immediately at specified rate within specified dissolution medium at 37 ± 0.5 °C. Aliquots should be withdrawn at specified time points or as mentioned in individual monograph and the volume of withdrawn sample should…
Hard gelatin capsules: IP uses disintegration test apparatus with 250 ml or 1L of specified disintegration medium maintained at 37 ± 2 °C and for specified time as per monograph. If 1–2 capsules fail, repeat for another 12 different units. 16 out of 18 capsules indicate that the test is affirmative. BP uses disintegration test apparatus…
This test is carried out using a capsule diameter sorter. The capsules are fed from the hopper into sorter and are allowed to pass into next unit maintained at 0.02 inch above the theoretical diameter of capsule. The equipment is provided with a vibrator so that capsules fit into operator.
The content of active ingredient in each of 10 capsules taken at random is determined according to the method given in the monograph or by following any other relevant analytical method of high accuracy and precision. The capsules pass the test if not more than one of the individual values is outside the specified limits…
Uniformity of Weight This test is only applicable to those capsules that need to comply with the test for uniformity of content of the main active ingredient. Weigh the capsule and open the capsule carefully without any spillage to remove the encapsulated contents completely. For soft gelatin capsules, the shell has to be washed with ether or…