Delivery of Monoclonal Antibody Using Semisolid Dosage Form

Lysostaphin was formulated into a hydrophilic cream, which forms an emulsion with the secretions of the nasal mucosa. Aqueous formulations were made containing the mucoadhesive polymers polystyrene sulfonate and chitosan. The results demonstrated that cream and polymer delivery systems significantly decreased the clearance rate of lysostaphin from the nose, thereby enhancing their therapeutic potential for eradicating Staphylococcus aureus nasal colonization.

Topical Delivery of Vitamin A

Burst release as well as sustained release of vitamin A can be obtained by using SLN suspensions. Burst release can be useful to improve the penetration of a drug. Sustained release becomes important with active ingredients that are irritating at high concentrations or to supply the skin over a prolonged period of time with a drug.

Glyceryl behenate SLN suspensions were loaded with vitamin A and the release profiles were studied using Franz diffusion cells to assess the release kinetic over a period of 24 hours.

Delivery of Epidermal Growth Factor by Topical Route

The effect of a topical recombinant human epidermal growth factor (rhEGF) ointment on the rate of wound healing and skin re-epithelialization in a rat full thickness wound model was carried out when rhEGF was applied topically to verify whether or not the rhEGF treatment affects both myofibroblast proliferation and collagen synthesis in the dermis. The results indicated significantly enhanced wound closure.

Topical Medications for Orofacial Neuropathic Pain

A vehicle-carrier agent (pluronic lecithin organogel) that can penetrate the mucosa and cutaneous tissues and carry the active medication with it to the treatment site was developed. Because of its rapid onset and low side effect profile, topical medication offered a distinct advantage over systemic administration for those orofacial disorders that are regional, near the surface and chronic.

Foam Drug Delivery

Pharmaceutical foams are pressurized dosage forms containing one or more active ingredients, which, upon valve actuation, emit a fine dispersion of liquid and/or solid materials in a gaseous medium. Foam formulations are generally easier to apply, less dense, and spread more easily than other topical dosage forms.

Foams may be formulated in various ways to provide emollient or drying functions to the skin, depending on the formulation constituents. Probably the most convincing argument for the use of foams is the ease of use by the patient and consumer acceptance. Most foam dosage forms used in dermatology to date have incorporated corticosteroids, although some products have also been used to deliver antiseptics, antifungal agents, anti-inflammatory agents, local anesthetic agents, skin emollients, and protectants.