Solid lipid nanoparticles (SLN) are solid colloidal particles that consist of biocompatible, biodegradable lipid matrix and exhibit size range between 100 nm and 400 nm. When administered parenterally, they showed protection of incorporated thermolabile drugs from degradation, good physical stability, controlled drug release depending on the incorporation of model, good tolerability and site-specific targeting. An example is prednisolone-loaded SLN.

Table 8.8 provides a list of USFDA-approved CR (controlled release) parenteral products.

Table 8.8 List of USFDA-approved CR parenteral products