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  • β-Pleated Sheets

    August 8, 2024
    Amino Acids

    β-pleated sheets form when two or more polypeptide chain segments line up side by side. Each individual segment is referred to as β-strand. Rather than being coiled, each β-strand is fully extended. β-pleated sheets are stabilised by hydrogen bonds that are formed between the polypeptide backbones N—H and carbonyl group of adjacent chain. There are…

  • NIEMANN–PICK DISEASE

    August 8, 2024
    Lipid Metabolism

    Deficiency of sphingomyeliase enzyme leads to Niemann–pick disease. Sphingomyelin cannot be degraded in the absence of the enzyme sphingomyelinase. In severe form, liver and spleen are the sites of lipid deposits, and they are enlarged. There is a large amount of sphingosine and a fatty acid.

  • α-helix

    August 8, 2024
    Amino Acids

    α-helix is spiral in shape and has a rigid arrangement of polypeptide chain as proposed by Pauling and Corey (1981). The salient features of α-helix are as follows: Figure 3.5 Structure of α-helix

  • DEGRADATION OF SPHINGOMYELIN

    August 8, 2024
    Lipid Metabolism

    Sphingomyelin is degraded by lysosomal enzyme sphingomyelinase to form ceramide and phosphorylcholine.

  • SECONDARY STRUCTURE

    August 8, 2024
    Amino Acids

    The protein gets folded, and the hydrogen bonding between the neighbouring amino acids results in the formation of a rigid and tubular structure called helix. This constitutes the secondary structure of proteins. Two types of secondary structure, α-helix and β-sheet, are mainly identified.

  • PLASMALOGENS

    August 8, 2024
    Lipid Metabolism

    When a fatty acid is attached by an ether linkage rather than by an ester linkage, at carbon 1 of the core glycerol molecule, a plasmalogen is produced. For example, phosphotidyl ethanolamine is the plasmalogen that is similar in structure to phosphotidyl ethanolamine. Myelin contains large amount of ethanolamine plasmalogen, and heart muscle contains large…

  • PRIMARY STRUCTURE – AMINO ACID SEQUENCE

    August 8, 2024
    Amino Acids

    The primary structure of protein refers to the number sequence of amino acids and the constituent units of polypeptide chain. The main mode of linkage of amino acids in proteins is the peptide bonds which link the α-carboxyl group of amino acid residue to the α-amino group of the other. Linus Pauling and Robert Corey…

  • PROTEIN CONFIGURATION

    August 8, 2024
    Amino Acids

    Linderstrom-Lang first defined the four basic structural levels of organisation, which are referred to as primary, secondary, tertiary, and quaternary. Three of these structural levels (primary, secondary, and tertiary) can exist in molecules composed of a single polypeptide chain, whereas the fourth (quaternary) involves interactions of polypeptide within a multi-chained protein molecule. The basic structure of…

  • CLASSIFICATION OF PROTEIN BASED ON NUTRITIONAL STATUS

    August 8, 2024
    Amino Acids

    The nutritive value of proteins is determined by the composition of essential amino acids. From the nutritional point of view, proteins are classified into three categories.

  • STRUCTURE

    August 8, 2024
    Lipid Metabolism

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